Multiverse Pharma Inc.

Creating the most selective and effective biotherapeutics.

Providing solutions to treat difficult diseases – neurodegeneration, brain cancer, and immune-mediated conditions.

Our Mission and Vision

Our mission is to engineer precision biologics that master both the “space” and “time” of disease. By leveraging our BBB RMT and Fc Heterodimerization platforms, we deliver therapies that precisely target the brain’s microenvironments and act within critical therapeutic windows. Our goal is to redefine treatment for neurodegeneration, glioblastoma, and other complex disorders through the development of selective, effective, and transformative therapies.

Beyond our pioneering CNS therapeutics, our portfolio features innovative programs such as MVP-523—a dual IL-12/23 blocker that modulates immune pathways implicated in inflammatory and autoimmune diseases—demonstrating our commitment to advancing targeted therapies across multiple disease areas.

We envision a future where no disease—neurological, oncological, or immunological—is untreatable. Our aspiration is to lead a new era in biotherapeutics by enabling drugs to cross the blood-brain barrier, engage targets with precision, and intervene at optimal moments, while expanding biologics to address urgent needs in other complex conditions.

Our Approach

At MVP, we accelerate biotherapeutic drug discovery with advanced research modules and cutting-edge biologic engineering. Our proprietary Fc heterodimerization platform enables the creation of efficient, stable, and manufacturable bi- and multispecific biologics for complex therapeutic challenges. Our BBB shuttle platform delivers biologic drugs safely and effectively to the brain, overcoming traditional neurotherapeutic barriers. By integrating computational and structure-guided methods, we rapidly develop biotherapeutics with enhanced safety and efficacy.

Through this multidisciplinary approach, MVP delivers next-generation solutions for patients.

MVP BBB Shuttle: Revolutionizing CNS Drug Delivery

The MVP BBB shuttle leverages receptor-mediated transcytosis to overcome the blood-brain barrier, targeting transporters distinct from TfR / CD98hc approaches.

Key Features & Advantages

Non-Competitive Mechanism

Engineered targeting motifs boost transcytosis efficiency over WT IgG, avoiding competition with natural transport pathways.

Modular Design

Integrates various payloads such as antibodies, enzymes, nucleotides using standard recombinant    methods for versatile CNS applications.

Preclinical Validation

Shows robust BBB penetration and favorable pharmacokinetics in human transgenic mouse models across doses.

Enhanced Therapeutic Potential

MVP’s proprietary Fc heterodimerization technology enables precise targeting through bi- and multispecifics.

Proprietary transgenic models optimize dosing and maximize AUC for scalable clinical translation.

By combining high efficacy, payload flexibility, and minimal off-target interference, the MVP BBB shuttle addresses critical CNS drug delivery challenges, offering a versatile solution for brain disorders.

MVP Heterodimerization

  • Significantly boosts heterodimer formation vs. traditional knob-in-hole tech
  • High expression yields via optimized plasmid ratios (transient levels >95%)
  • Engineered Fc enhances specificity, suppresses byproducts (validated by multi-analysis)
  • Wild-type-like thermostability outperforms knob-in-hole; ensures structural integrity and manufacturability
  • Drug-conjugation compatible, reduces aggregation, retains Fc functions

MVP Multispecific Therapeutics

MVP-523, a deimmunized IL12/IL23 dual inhibitor, offers 5x the potency of ustekinumab while maintaining its safety and stability. Ready for spin-off, it acts as a standalone therapy or a base for trispecific designs addressing unmet IBD (UC/CD) needs, using our heterodimerization platform for molecular integrity.

MVP’s platform supports stable, manufacturable bi-and multispecifics, validated with or without BBB shuttles, enabling scalable, next-gen therapies with precision for complex inflammatory, neurological, and other diseases.

Project Portfolio

Therapeutic Area

Neuro + Neuro Oncology

Immunology + Inflammation

Oncology

Any: Bi-, Multispecifics

Project

1. MVP-104 Ab
2. BBB-2 Ab

3. MVP-523 Ab

4. AB for an undisclosed target

5. Heterodimeric Fc

Stage

In vivo tested
In vivo testing

Ready for spin-off

Lead Optimization

Completed

Ownership

100%

100%

100%

100%

Partnership(s)

Proprietary
Proprietary

Licensing Available

Proprietary

Licensing Available

Our Team

All Multiverse FTEs are industry experts 100% committed to developing biotherapeutics. Proven advisors sharpen discovery sciences, translation studies, and drug candidate profiles.

Jeonghoon Sun

PhD, CEO & Founder, Antibody & Protein Engineering

  • 20+ years of biotherapeutics R & D, worked at Amgen, Eli Lilly, Celgene, Alector
  • 40+ projects: Antibody and protein engineering, bi-, multispecifics, BBB
  • 8 biologics to clinical including ActRIIB, CC-90006 PD-1, CC-95251 SIRPa-K322A, CC-90002 CD47
  • 50+ patents and research papers
  • SUNY Stony Brook PhD, Chemistry, UCSF US Dept of Defense postdoctoral fellow, Protein Engineering

Brydon Bennett

PhD, CSO, Biology Head, Immunology & Autoimmune Diseases

  • 20+ years of Inflammation & Immunology; Therapeutic Area Leader
  • 7 drugs nominated for clinical development, CC-220 Phase 3, CC-90001 Phase 2, CC-90005 Phase 1
  • 65+ papers and 35+ US patents
  • University of Otago, New Zealand, BSc Hons, PhD, biochemistry and molecular biology, Postdoc- the Upjohn Company, NF-kB pathway & transcriptional control

David Lin

PhD, Principal Scientist, Blood Brain Barrier, Cell Biology

  • 10+ years of industry experience in Ab discovery , 20+ papers and patents
  • Expert in BBB biology, B cell cloning, various animal models in neurological disorders cardiovascular and metabolic diseases, cell-based functional assay, bio-layer Interferometry, multi-color FACS, histology, IHC/ICC/ISH, surgery, dosing
  • PhD in Biomedical Science, UC San Diego; Postdoc at the Scripps; Senior Fellow at U of Washington

Gregory Reyes

MD, PhD, Advisor

  • 30+ years leader in biopharma
  • Drug Discovery at Celgene, Biogen, Pfizer, Schering-Plough
  • 50+ drugs for preclinical / clinical
  • 2012 Prix Galien Award by Victrelisâ„¢
  • 100+ papers and 50+ patents

Nicole Sampson

PhD, Advisor

  • UC Berkeley PhD, Harvard postdoc
  • Provost / Chief Academic Officer, University of Rochester
  • Former Distinguished Professor, Chemistry / Dean, College of Arts and Sciences, SUNY Stony Brook
  • Fellow: American Chemical Society

Latest News

Contact Us

If you are interested to learn more about our mission at Multiverse Pharma Inc and to explore collaboration opportunities, please reach out with your contact details!

Email:

Address:

Operating at Biolabs at 9276 Scranton Rd, STE 500, San Diego CA 92121, U.S.A.

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